Biological Activity
Non-peptide calcitonin (CT) receptor agonist that fully stimulates cAMP production in CHO/hCTR cells (EC50 = 21 μM). Causes a significant reduction in serum calcium concentrations in vivo following i.p. administration.
Compound Libraries
SUN-B 8155 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 273.29 |
| Formula | C14H15N3O3 |
| Storage | Store at +4°C |
| CAS Number | 345893-91-6 |
| PubChem ID | 16079007 |
| InChI Key | IMUCOECFKIWBSW-LCYFTJDESA-N |
| Smiles | O=C1C=C(C)C(/C(C)=N/C2=C(N)C=CC=C2)=C(O)N1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.32 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 273.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.66 mL | 18.3 mL | 36.59 mL |
| 5 mM | 0.73 mL | 3.66 mL | 7.32 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Katayama et al (2001) Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin. Biochim.Biophys.Acta 1526 183 PMID: 11325540
Keywords: SUN-B 8155, supplier, Non-peptide, calcitonin, CT, receptors, agonists, SUNB8155, Calcitonin, and, Related, Receptors, Calcitonin, and, Related, Receptors, Tocris Bioscience
