Biological Activity
High affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.
Technical Data
| M. Wt | 412.59 |
| Formula | C21H20N2OS3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 459147-39-8 |
| PubChem ID | 3337839 |
| InChI Key | LCYAYKSMOVLVRL-UHFFFAOYSA-N |
| Smiles | NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.26 | 100 | |
| ethanol | 8.25 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 412.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.12 mL | 24.24 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.85 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Zhang et al (2015) Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 345 aaa2340 PMID: 26068857
Keywords: SW 033291, supplier, SW033291, 15-PGDH, hydroxyprostaglandin, dehydrogenase, inhibitors, inhibits, hematopoiesis, hematopoietic, hepatocyte, proliferation, PGE2, Other, Dehydrogenases, Stem, Cell, Proliferation, Other, Dehydrogenases, Tocris Bioscience
