Biological Activity
Potent p38α inhibitor (IC50 = 9 nM). Also inhibits p38β and JNK-2 (IC50 values are 90 nM and 100 nM respectively). Displays no significant activity at p38γ, p38δ, ERK-2 and JNK-1.
Technical Data
| M. Wt | 483.96 |
| Formula | C26H27ClFN3O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 309913-42-6 |
| PubChem ID | 9935015 |
| InChI Key | GUTYHDCSDBBMGW-UHFFFAOYSA-N |
| Smiles | O=C(C(N(C)C)=O)C2=CN(C)C1=CC(Cl)=C(C(N3CCC(CC4=CC=C(F)C=C4)CC3)=O)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.4 | 100 | |
| ethanol | 48.4 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 483.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.07 mL | 10.33 mL | 20.66 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.13 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.07 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lee and Dominguez (2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 12 2979 PMID: 16378500
Keywords: SX 011, supplier, SX011, p38, inhibitors, inhibits, MAPK, p38alpha, p38beta, p38a, p38b, signaling, signalling, Mitogen-Activated, Protein, Kinases, p38, p38, Tocris Bioscience
