BiologicalActivity
Potentandhighlyselectivekainatereceptoragonist,withanIC50forinhibitionof[3H]-kainatebindingof35nMandalmost3,000-and200-foldselectivityforkainatereceptorsoverAMPAandNMDAreceptorsrespectively.AlsoselectivelyinhibitstheclonedexcitatoryaminoacidtransporterEAAT2athigherconcentrations.AlsoavailableaspartoftheExcitatoryAminoAcidTransporterInhibitorTocriset™andKainateReceptorTocriset™.
LicensingInformation
SoldwiththepermissionofAnnovisInc.
TechnicalData
| M.Wt | 161.16 |
| Formula | C6H11NO4 |
| Storage | StoreatRT |
| Purity | ≥97%(HPLC) |
| CASNumber | 31137-74-3 |
| PubChemID | 95883 |
| InChIKey | KRKRAOXTGDJWNI-DMTCNVIQSA-N |
| Smiles | [H][C@@](N)(C(O)=O)C[C@]([H])([C@](O)=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| phosphatebufferedsaline | 8.06 | 50 | |
| 1eq.NaOH | 16.12 | 100 | |
| water | 8.06 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight161.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 6.21mL | 31.03mL | 62.05mL |
| 5mM | 1.24mL | 6.21mL | 12.41mL |
| 10mM | 0.62mL | 3.1mL | 6.21mL |
| 50mM | 0.12mL | 0.62mL | 1.24mL |
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