Tocris/SZL P1-41/5076/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/SZL P1-41/5076/10/10 mg

Tocris/SZL P1-41/5076/10/10 mg

商品编号： 5076/10

品牌： Tocris Bioscience

市场价： ¥3980.00

美元价： 2388.00

产地：美国(厂家直采)

公司：

产品分类：连接酶

公司分类： ligase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:SelectiveSkp2inhibitor;suppressesE3ligaseactivity

ChemicalName:3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Skp2inhibitor;thoughttopreventassemblyofSkp2-Skp1complexes.SelectivelysuppressesSkp2SCFE3ligaseactivitybutexhibitsnoeffectontheactivityofotherSCFcomplexes.AlsoinhibitsSkp2-mediatedp27andAktubiquitinationinvivoandinvitro.Suppressesthesurvivalofcancercellsandcancerstemcellsbytriggeringcellsenescenceandinhibitingglycolysis.Exhibitsantitumoreffectsinmultipleanimalmodelsandcancercelllines.

TechnicalData

M.Wt	420.52
Formula	C₂₄H₂₄N₂O₃S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	222716-34-9
PubChemID	1286902
InChIKey	JKIXLEKBXHMXTN-UHFFFAOYSA-N
Smiles	OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	8.41	20
	DMSO	2.1	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight420.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.38mL	11.89mL	23.78mL
5mM	0.48mL	2.38mL	4.76mL
10mM	0.24mL	1.19mL	2.38mL
50mM	0.05mL	0.24mL	0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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