Biological Activity
Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.
Technical Data
| M. Wt | 358.54 |
| Formula | C22H30O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 162520-00-5 |
| PubChem ID | 5469318 |
| InChI Key | WUILNKCFCLNXOK-CFBAGHHKSA-N |
| Smiles | CC(CC/C=C(C)/CC/C=C(C)/C)=C/CSC1=CC=CC=C1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 17.93 | 50 | |
| DMSO | 35.85 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 358.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.79 mL | 13.95 mL | 27.89 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.58 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.79 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Schmukler et al (2013) Ras inhibition enhances autophagy, which partially protects cells from death. Oncotarget 4 142 PMID: 23370967
Faigenbaum et al (2013) Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. Oncotarget 4 316 PMID: 23530112
Haklai et al (1998) Dislodgement and accelerated degradation of Ras. Biochemistry 37 1306 PMID: 9477957
Keywords: Salirasib, supplier, Ras, inhibitors, inhibits, induces, autophagy, GTPase, G, Proteins, (Small), Autophagy, GTPase, Tocris Bioscience
