Biological Activity
Competitive non-selective angiotensin II antagonist.
Technical Data
| M. Wt | 912 |
| Formula | C42H65N13O10 |
| Sequence |
XRVYVHPA (Modifications: X = Sar) |
| Storage | Desiccate at -20°C |
| CAS Number | 34273-10-4 |
| PubChem ID | 6324663 |
| InChI Key | PFGWGEPQIUAZME-NXSMLHPHSA-N |
| Smiles | [H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 912. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.1 mL | 5.48 mL | 10.96 mL |
| 5 mM | 0.22 mL | 1.1 mL | 2.19 mL |
| 10 mM | 0.11 mL | 0.55 mL | 1.1 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
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References
References are publications that support the products' biological activity.
Steinhausen et al (1986) Angiotensin II control of the renal microcirculation: effect of blockade by saralasin. Kidney Int. 30 56 PMID: 3747343
Thomas et al (1995) Saralasin suppresses arrhythmias in an isolated guinea-pig ventricular free wall model of simulated ischemia and reperfusion. J.Pharmacol.Exp.Ther. 274 1379 PMID: 7562511
Keywords: Saralasin, supplier, Non-Selective, angiotensin, II, antagonist, AT, Receptors, Non-selective, AT, Receptors, Non-selective, AT, Receptors, Tocris Bioscience
