Biological Activity
Endogenous inhibitor of GlyT1 that displays antipsychotic activity. Potentiates the action of glycine on the NMDA glycine binding site.
Technical Data
| M. Wt | 89.09 |
| Formula | C3H7NO2 |
| Storage | Store at RT |
| CAS Number | 107-97-1 |
| PubChem ID | 1088 |
| InChI Key | FSYKKLYZXJSNPZ-UHFFFAOYSA-N |
| Smiles | OC(CNC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.91 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 89.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 11.22 mL | 56.12 mL | 112.25 mL |
| 5 mM | 2.24 mL | 11.22 mL | 22.45 mL |
| 10 mM | 1.12 mL | 5.61 mL | 11.22 mL |
| 50 mM | 0.22 mL | 1.12 mL | 2.24 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Tsai et al (2004) Glycine transporter I inhibitor, N-methylglycine (Sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol.Psychiatry 55 452 PMID: 15023571
Singh and Singh (2011) Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs. 25 859 PMID: 21936588
Keywords: Sarcosine, supplier, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, Glycine, Transporters, Glycine, Transporters, Tocris Bioscience
