Biological Activity
Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
Technical Data
| M. Wt | 384.27 |
| Formula | C17H21NO4.HBr |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 114-49-8 |
| PubChem ID | 45073445 |
| InChI Key | WMRMIRRDPBKNMY-ZEECNFPPSA-N |
| Smiles | O=C([C@@H]([C@]3=CC=CC=C3)CO)O[C@H]1C[C@H]4[C@H](O2)[C@H]2[C@H](N4C)C1.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.21 | 50 | |
| water | 38.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 384.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.6 mL | 13.01 mL | 26.02 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Jones and Shannon (2000) Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats. Eur.J.Pharmacol. 391 105 PMID: 10720641
Nakao et al (1999) Cerebral blood flow responses to somatosensory stimulation are unaffected by scopolamine in unanesthetized rat. J.Pharmacol.Exp.Ther. 290 929 PMID: 10411611
Parkes (1965) An examination of central actions characteristic of scopolamine: comparison of central and peripheral activity in scopolamine, atropine and some synthetic basic esters. Psychopharmacologia 7 1 PMID: 5830966
Keywords: Scopolamine hydrobromide, supplier, Non-Selective, muscarinic, antagonist, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, Non-selective, Muscarinics, Tocris Bioscience
