Biological Activity
Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.
Compound Libraries
Scriptaid is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 326.35 |
| Formula | C18H18N2O4 |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 287383-59-9 |
| PubChem ID | 5186 |
| InChI Key | JTDYUFSDZATMKU-UHFFFAOYSA-N |
| Smiles | ONC(=O)CCCCCN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 326.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.06 mL | 15.32 mL | 30.64 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.13 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.06 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Su et al (2000) A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 60 3137 PMID: 10866300
Keywords: Scriptaid, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience
