Biological Activity
Gastrointestinal peptide that stimulates pancreatic and biliary secretion. Also thought to play a role in the regulation of the hypothalamus-pituitary-adrenal axis.
Technical Data
| M. Wt | 3039.44 |
| Formula | C130H220N44O40 |
| Sequence |
HSDGTFTSELSRLREGARLQRLLQGLV (Modifications: Val-27 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 108153-74-8 |
| PubChem ID | 16158474 |
| InChI Key | OWMZNFCDEHGFEP-NFBCVYDUSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3039.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.33 mL | 1.65 mL | 3.29 mL |
| 5 mM | 0.07 mL | 0.33 mL | 0.66 mL |
| 10 mM | 0.03 mL | 0.16 mL | 0.33 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.07 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Nussdorfer et al (2000) Secretin, glucagon, gastric inhibitor polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus-pituitary-adrenal axis. Peptides 21 309 PMID: 10764961
Sherwood et al (2000) The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/Glucagon superfamily. Endocr.Rev. 21 619 PMID: 11133067
Keywords: Secretin (human), supplier, Gastrointestinal, peptide, Secretin, Receptors, Glucagon, Secretin, Receptors, Secretin, Receptors, Tocris Bioscience
