Biological Activity
Cyclin-dependent kinase 8 (cdk8) inhibitor (IC50 = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin-induced tumor-promoting paracrine activities in vivo.
Licensing Information
Sold under license from Senex Biotechnology.
Technical Data
| M. Wt | 310.78 |
| Formula | C17H14N4.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 90488980 |
| InChI Key | POENYXHGUHRXFR-UHFFFAOYSA-N |
| Smiles | N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.08 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 310.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.22 mL | 16.09 mL | 32.18 mL |
| 5 mM | 0.64 mL | 3.22 mL | 6.44 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.22 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Porter et al (2012) Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc.Natl.Acad.Sci.U.S.A. 109 13799 PMID: 22869755
Keywords: Senexin A, supplier, cyclin, dependent, kinases, cdks, cdk8, cdk19, inhibits, inhibitors, p21, transcription, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience
