Biological Activity
NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.
Technical Data
| M. Wt | 841.97 |
| Formula | C40H55N7O11S |
| Sequence |
DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 106128-89-6 |
| PubChem ID | 90479751 |
| InChI Key | UGXWLDUHYDFTIA-QKUYTOGTSA-N |
| Smiles | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1=CC=C(C)C=C1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in PBS (pH 7.4) |
Preparing Stock Solutions
The following data is based on the product molecular weight 841.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.19 mL | 5.94 mL | 11.88 mL |
| 5 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 10 mM | 0.12 mL | 0.59 mL | 1.19 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
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References
References are publications that support the products' biological activity.
Keegan et al (1992) The selective NK receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br.J.Pharmacol. 105 3 PMID: 1375857
Nordquist et al (2008) The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur.J.Pharmacol. 600 87 PMID: 18930726
Renzetti et al (1991) Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide. Neuropeptides 18 107 PMID: 1712430
Keywords: Senktide, supplier, Tachykinin, NK3, agonists, Receptors, Neurokinin, NK3, Receptor, NK3, Receptor, Tocris Bioscience
