Biological Activity
Potent, orally active selective serotonin re-uptake inhibitor (SSRI); antidepressant.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries
Sertraline hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 342.69 |
| Formula | C17H17Cl2N.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 79559-97-0 |
| PubChem ID | 63009 |
| InChI Key | BLFQGGGGFNSJKA-XHXSRVRCSA-N |
| Smiles | ClC(C(Cl)=C3)=CC=[C@@]3[C@H]2C1=CC=CC=C1[C@@H](NC)CC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.26 | 100 | |
| ethanol | 17.13 | 50 | |
| water | 1.71 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 342.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.59 mL | 29.18 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Koe et al (1983) Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J.Pharmacol.Exp.Ther. 226 686 PMID: 6310078
Heym and Koe (1988) Pharmacology of sertraline: a review. J.Clin.Psychiatry 49 40 PMID: 3045112
Doogan and Caillard (1988) Sertraline: a new antidepressant. J.Clin.Psychiatry. 49 46 PMID:
Keywords: Sertraline hydrochloride, supplier, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Pfizer, ssri, 5-HT, Transporters, 5-HT, Transporters, Tocris Bioscience
