Biological Activity
Endogenous peptide; inhibits the release of growth hormone, insulin and glucagon. Inhibits voltage-dependent calcium channels.
Technical Data
| M. Wt | 1637.88 |
| Formula | C76H104N18O19S2 |
| Sequence |
AGCKNFFWKTFTSC (Modifications: Disulfide bridge between 3 - 14) |
| Storage | Desiccate at -20°C |
| CAS Number | 51110-01-1 |
| PubChem ID | 16129706 |
| InChI Key | NHXLMOGPVYXJNR-ATOGVRKGSA-N |
| Smiles | [H]N[C@@H](C)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.30 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1637.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.61 mL | 3.05 mL | 6.11 mL |
| 5 mM | 0.12 mL | 0.61 mL | 1.22 mL |
| 10 mM | 0.06 mL | 0.31 mL | 0.61 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.12 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Alderton et al (1998) Differential effects of somatostatin and angiopeptin on cell proliferation. Br.J.Pharmacol. 124 323 PMID: 9641549
Dileepan et al (1985) Somatostatin: a metabolic regulator. Life Sci. 37 2335 PMID: 2867445
Ohmura et al (1990) Somatostatin decreases the calcium inward current in guinea-pig atria. Br.J.Pharmacol. 99 587 PMID: 1970502
Keywords: Somatostatin, supplier, Influences, growth, hormone, release, sst, Receptors, Somatostatin, Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience
