Biological Activity
Somatostatin receptor agonist, derived from the post-translational cleavage of prosomatostatin.
Technical Data
| M. Wt | 3149 |
| Formula | C137H207N41O39S3 |
| Sequence |
SANSNPAMAPRERKAGCKNFFWKTFTSC (Modifications: Disulfide bridge between 17 - 28) |
| Storage | Desiccate at -20°C |
| CAS Number | 74315-46-1 |
| PubChem ID | 16133849 |
| InChI Key | GGYTXJNZMFRSLX-DFTNLTQTSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.50 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3149. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 5 mM | 0.06 mL | 0.32 mL | 0.64 mL |
| 10 mM | 0.03 mL | 0.16 mL | 0.32 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.06 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Panetta et al (1994) Molecular cloning, functional characterization and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. Mol.Pharmacol. 45 417 PMID: 7908405
Patel et al (1994) Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype. J.Biol.Chem. 269 1506 PMID: 7904601
Shimokawa et al (1997) Effect of somatostatin-28 on growth hormone response to growth hormone-releasing hormone-impact of aging and lifelong dietary restriction. Neuroendocrinol. 65 369 PMID: 9158069
Keywords: Somatostatin 1-28, supplier, Somatostatin, receptor, agonist, sst, Receptors, Somatostatin1-28, Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience
