Biological Activity
A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™.
Technical Data
| M. Wt | 308.82 |
| Formula | C12H20N2O3S.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 959-24-0 |
| PubChem ID | 66245 |
| InChI Key | VIDRYROWYFWGSY-UHFFFAOYSA-N |
| Smiles | Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 30.88 | 100 | |
| water | 15.44 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 308.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.19 mL | 32.38 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.48 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451 PMID: 7770366
Fiset et al (1997) Block of Iks by the diuretic agent indapamide modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148 PMID: 9336319
Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88 PMID: 6006227
Merck Index 12 8876 PMID:
Keywords: Sotalol hydrochloride, supplier, β-adrenoceptor, beta-adrenoceptors, b-adrenergic, β-adrenergic, beta-adrenergic, b-adrenoceptors, antagonists, Receptors, Non-Selective, Non-selective, Adrenergic, Beta, Receptors, Non-selective, Adrenergic, Beta, Receptors, Tocris Bioscience
