BiologicalActivity
Inhibitorofautophagy;inhibitsUSP10andUSP13activity(IC50valuesare0.6and0.7μMrespectively)andpromotesdegradationofVps34(classIIIPI3-kinase)complexes.Selectivelypromotesapoptosisofcancercellsunderstarvationconditions.PreventsthePDGF-inducedconversionfromthecontractiletosyntheticphenotypeinvascularsmoothmusclecells.
CompoundLibraries
Spautin1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 271.26 |
| Formula | C15H11F2N3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1262888-28-7 |
| PubChemID | 51037431 |
| InChIKey | AWIVHRPYFSSVOG-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(N=CN=C2NCC3=CC=C(F)C=C3)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.13 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight271.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.69mL | 18.43mL | 36.87mL |
| 5mM | 0.74mL | 3.69mL | 7.37mL |
| 10mM | 0.37mL | 1.84mL | 3.69mL |
| 50mM | 0.07mL | 0.37mL | 0.74mL |
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ProductDatasheets
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