Biological Activity
Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801. Activates autophagy.
Technical Data
| M. Wt | 254.63 |
| Formula | C7H19N3.3HCl |
| Storage | Desiccate at +4°C |
| CAS Number | 334-50-9 |
| PubChem ID | 9539 |
| InChI Key | LCNBIHVSOPXFMR-UHFFFAOYSA-N |
| Smiles | Cl.Cl.Cl.NCCCCNCCCN |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 254.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.93 mL | 19.64 mL | 39.27 mL |
| 5 mM | 0.79 mL | 3.93 mL | 7.85 mL |
| 10 mM | 0.39 mL | 1.96 mL | 3.93 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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References
References are publications that support the products' biological activity.
Kishi et al (1998) Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res. 793 311 PMID: 9630697
Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163 PMID: 8358608
Williams et al (1989) Effects of polyamines on the binding of [3H]-MK801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol.Pharmacol. 36 375 PMID: 2554112
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
Keywords: Spermidine trihydrochloride, supplier, Agonist, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, NMDA, Receptors, Autophagy, NMDA, Receptors, Tocris Bioscience
