Biological Activity
A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC50 = 6.2 μM for relaxation of rabbit aorta, and t½ =39 min at 37°C, pH 7.4, aqueous solution).
Licensing Information
Sold with the permission of the NIH, US Patent 5,155,137
Technical Data
| M. Wt | 262.35 |
| Formula | C10H26N6O2 |
| Storage | Desiccate at -20°C |
| CAS Number | 136587-13-8 |
| PubChem ID | 5259 |
| InChI Key | QPIOUFBAROSIAN-UHFFFAOYSA-N |
| Smiles | NCCCN(N(O)N=O)CCCCNCCCN |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.23 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 262.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.81 mL | 19.06 mL | 38.12 mL |
| 5 mM | 0.76 mL | 3.81 mL | 7.62 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.81 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570
Homer and Wanstall (1998) In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur.J.Pharmacol. 356 49 PMID: 9761423
Maragos et al (1991) Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J.Med.Chem. 34 3242 PMID: 1956043
Ramamurthi and Lewis (1997) Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem.Res.Toxicol. 10 408 PMID: 9114977
Keywords: Spermine NONOate, supplier, Slow, NO, releasing, agent, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, NO, Donors, /, Precursors, ROS, Donors, NO, Donors, /, Precursors, Tocris Bioscience
