Biological Activity
Endogenous peptide; inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.
Technical Data
| M. Wt | 877.05 |
| Formula | C45H64N8O10 |
| Sequence | LVVYPWT |
| Storage | Desiccate at -20°C |
| CAS Number | 137201-62-8 |
| PubChem ID | 3081832 |
| InChI Key | BXIFNVGZIMFBQB-DYDSHOKNSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 877.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.14 mL | 5.7 mL | 11.4 mL |
| 5 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 10 mM | 0.11 mL | 0.57 mL | 1.14 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.23 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Honda et al (2001) Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn.J.Pharmacol. 87 261 PMID: 11829145
Liang et al (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J.Immunol. 167 6609 PMID: 11714831
Keywords: Spinorphin, supplier, Potent, P2X3, antagonists, Enkephalin-degrading, ACE, inhibitors, inhibits, Receptors, Purinergic, purinoceptors, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Other, Proteases, Angiotensin-Converting, Enzyme, Angiotensin-Converting, Enzyme, Tocris Bioscience
