Biological Activity
5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.
Technical Data
| M. Wt | 431.94 |
| Formula | C23H26FN3O2.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 2022-29-9 |
| PubChem ID | 11957687 |
| InChI Key | QUIKMLCZZMOBLH-UHFFFAOYSA-N |
| Smiles | Cl.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.19 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 431.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.58 mL | 23.15 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Seeman and van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991
Merck Index 12 8903 PMID:
Keywords: Spiperone hydrochloride, supplier, D2-like, antagonists, 5-HT2A, Dopamine, Non-Selective, Receptors, Serotonin, dopaminergic, 5-HT2A, Receptors, Non-selective, Dopamine, 5-HT2A, Receptors, Tocris Bioscience
