Biological Activity
Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
Compound Libraries
Splitomicin is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 198.22 |
| Formula | C13H10O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 5690-03-9 |
| PubChem ID | 5269 |
| InChI Key | ISFPDBUKMJDAJH-UHFFFAOYSA-N |
| Smiles | O=C1CCC2=C(O1)C=CC1=CC=CC=C21 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.82 | 100 | |
| ethanol | 19.82 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 198.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.04 mL | 25.22 mL | 50.45 mL |
| 5 mM | 1.01 mL | 5.04 mL | 10.09 mL |
| 10 mM | 0.5 mL | 2.52 mL | 5.04 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1.01 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Bedalov et al (2001) Identification of a small molecule inhibitor of Sir2p. Proc.Natl.Acad.Sci.U.S.A. 98 15113 PMID: 11752457
Keywords: Splitomicin, supplier, Sir2p, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Sir2-like, Family, Deacetylases, Sir2-like, Family, Deacetylases, Tocris Bioscience
