Biological Activity
Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
Technical Data
| M. Wt | 211.19 |
| Formula | C8H5NO4S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 19983-44-9 |
| PubChem ID | 2779853 |
| InChI Key | ZRRGOUHITGRLBA-UHFFFAOYSA-N |
| Smiles | O=S2(C1=CC([N+]([O-])=O)=CC=C1C=C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.56 | 50 | |
| ethanol | 1.06 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 211.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.74 mL | 23.68 mL | 47.35 mL |
| 5 mM | 0.95 mL | 4.74 mL | 9.47 mL |
| 10 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.95 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235 PMID: 17114005
Keywords: Stattic, supplier, Selective, STAT3, inhibitors, inhibits, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, STAT, STAT, Tocris Bioscience
