Biological Activity
Small molecule that primes embryonic stem cells (ESCs) for differentiation. Interacts with NME2 and inhibits its nuclear translocation. Increases the efficiency of directed differentiation of mouse and human ESCs in vitro.
Technical Data
| M. Wt | 584.62 |
| Formula | C35H28N4O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 154589-96-5 |
| PubChem ID | 46245328 |
| InChI Key | MQCCJEYZKWZQHU-MPRCCEKMSA-N |
| Smiles | O=C(NC6=O)C1=C6C4=C3C2=C1C8=C(C=CC=C8)N2[C@](C[C@@H](N(C(C9=CC=CC=C9)=O)C)[C@H]7OC)([H])O[C@]7(C)N3C5=CC=CC=C45 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 584.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.71 mL | 8.55 mL | 17.11 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.71 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Zhu et al (2009) A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell. 4 416 PMID: 19427291
Keywords: Stauprimide, supplier, embryonic, stem, cells, ESCs, differentiation, inhibitors, inhibits, NME2, nuclear, translocation, transcription, factors, primes, Other, Transcription, Factors, ESCs, and, iPSC, Other, Transcription, Factors, Tocris Bioscience
