Biological Activity
Sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.
Technical Data
| M. Wt | 1347.6 |
| Formula | C63H98N18O13S |
| Sequence |
RPKPQQFFGLM (Modifications: Met-11 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 33507-63-0 |
| PubChem ID | 36511 |
| InChI Key | ADNPLDHMAVUMIW-CUZNLEPHSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.80 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1347.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.74 mL | 3.71 mL | 7.42 mL |
| 5 mM | 0.15 mL | 0.74 mL | 1.48 mL |
| 10 mM | 0.07 mL | 0.37 mL | 0.74 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140 PMID: 9732370
Pernow et al (1983) Substance P. Pharmacol.Rev. 35 85 PMID: 6196797
Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343 PMID: 7541689
Merck Index 12 9032 PMID:
Keywords: Substance P, supplier, Sensory, neuropeptide, inflammatory, mediators, Tachykinin, Non-Selective, Neurokinin, Receptors, agonists, SubstanceP, neuropeptides, Other, Tachykinin, Other, Tachykinin, Tocris Bioscience
