Biological Activity
A selective ETA endothelin receptor antagonist (IC50 values are 600 and 2200 nM for ETA and ETB receptors respectively).
Technical Data
| M. Wt | 267.3 |
| Formula | C11H13N3O3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 127-69-5 |
| PubChem ID | 5344 |
| InChI Key | NHUHCSRWZMLRLA-UHFFFAOYSA-N |
| Smiles | CC1=NOC(NS(=O)(=O)C2=CC=C(N)C=C2)=C1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 267.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.74 mL | 18.71 mL | 37.41 mL |
| 5 mM | 0.75 mL | 3.74 mL | 7.48 mL |
| 10 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Chan et al (1994) Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem.Biophys.Res.Commun. 201 228 PMID: 8198578
Keywords: Sulfisoxazole, supplier, Endothelin, ETA, antagonists, Receptors, Endothelin, ETA, Receptors, Endothelin, ETA, Receptors, Tocris Bioscience
