BiologicalActivity
Potent,ATP-competitiveVEGFR,PDGFRβandKITinhibitor(Kivaluesare2,9,17,8and4nMforVEGFR-1,-2,-3,PDGFRβandKITrespectively).AlsoinhibitscellularreceptorphosphorylationofFLT3,RETandCSF-1R.Exhibitsantiangiogenicandantitumoractivityinmultiplexenograftmodels.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
SunitinibmalateisalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 532.56 |
| Formula | C22H27FN4O2.C4H6O5 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 341031-54-7 |
| PubChemID | 6456015 |
| InChIKey | LBWFXVZLPYTWQI-IPOVEDGCSA-N |
| Smiles | O=C(NCCN(CC)CC)C1=C(C)NC(/C=C2C(NC3=C2C=C(F)C=C3)=O)=C1C.OC(C[C@H](O)C(O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.31 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight532.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.88mL | 9.39mL | 18.78mL |
| 5mM | 0.38mL | 1.88mL | 3.76mL |
| 10mM | 0.19mL | 0.94mL | 1.88mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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ProductDatasheets
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