Biological Activity
Th4 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
Technical Data
| M. Wt | 499.64 |
| Formula | C16H26NO4S.C7H7O3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 94055-76-2 |
| PubChem ID | 71773 |
| InChI Key | RYVJQEZJUFRANT-UHFFFAOYSA-N |
| Smiles | O=C(CC[S+](C)C)NC1=CC=C(OCC(O)COCC)C=C1.CC2=CC=C(S(=O)([O-])=O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.96 | 100 | |
| ethanol | 49.96 | 100 | |
| water | 49.96 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 499.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 10.01 mL | 20.01 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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References
References are publications that support the products' biological activity.
Kurokawa et al (2001) Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo. Mediators Inflamm. 10 333 PMID: 11817674
Hsu et al (2007) The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells. Transpl.Immunol. 18 108 PMID: 18005853
Furonaka et al (2009) Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice. J.Pharmacol.Exp.Ther. 328 55 PMID: 18832650
Keywords: Suplatast tosylate, supplier, Th4, cytokine, synthesis, inhibitors, inhibits, antiasthmatic, TNF-α, TNF-alpha, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, IPD1151T, IPD, 1151T, Cytokines, Cytokines, Tocris Bioscience
