Biological Activity
Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.
Technical Data
| M. Wt | 1429.15 |
| Formula | C51H34N6Na6O23S6 |
| Storage | Store at RT |
| CAS Number | 129-46-4 |
| PubChem ID | 5360 |
| InChI Key | VAPNKLKDKUDFHK-UHFFFAOYSA-H |
| Smiles | [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=C3C(C=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C2)S([O-])(=O)=O)=C1)C(=O)NC1=C2C(C=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C1)S([O-])(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.29 | 10 | |
| water | 71.46 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 1429.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.7 mL | 3.5 mL | 7 mL |
| 5 mM | 0.14 mL | 0.7 mL | 1.4 mL |
| 10 mM | 0.07 mL | 0.35 mL | 0.7 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Beindl et al (1996) Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. 50 415 PMID: 8700151
Charlton et al (1996) PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br.J.Pharmacol. 118 704 PMID: 8762097
Klinger et al (2001) Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem.J. 355 827 PMID: 11311147
Voogd et al (1993) Recent research on the biological activity of suramin. Pharmacol.Rev. 45 177 PMID: 8396782
Hill et al (2004) Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. Mol.Pharmacol. 65 1258 PMID: 15102954
Keywords: Suramin hexasodium salt, supplier, Non-Selective, P2, antagonists, P2X, P2Y, Uncouples, G, proteins, from, receptors, heterotrimeric, purinoceptors, ryanodine, receptors, ion, channels, P2X, Receptors, G, Protein, (Heterotrimeric), Purinergic, P2Y, Receptors, Antivirals, Ryanodine, Receptors, P2X, Receptors, Tocris Bioscience
