Biological Activity
Inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.
Technical Data
| M. Wt | 173.21 |
| Formula | C8H15NO3 |
| Storage | Store at -20°C |
| CAS Number | 72741-87-8 |
| PubChem ID | 51683 |
| InChI Key | FXUAIOOAOAVCGD-WCTZXXKLSA-N |
| Smiles | O[C@@H]2[C@H](O)CN1CCC[C@@H](O)[C@@]12[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.66 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.77 mL | 28.87 mL | 57.73 mL |
| 5 mM | 1.15 mL | 5.77 mL | 11.55 mL |
| 10 mM | 0.58 mL | 2.89 mL | 5.77 mL |
| 50 mM | 0.12 mL | 0.58 mL | 1.15 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Tulsiani et al (1982) Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. J.Biol.Chem. 257 7936 PMID: 6806288
Olden et al (1991) The potential importance of swainsonine in therapy for cancers and immunology. Pharmacol.Ther. 50 285 PMID: 1754603
Sun et al (2007) Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 14 353 PMID: 17097281
Keywords: Swainsonine, supplier, inhibitors, inhibits, α-mannosidase, alpha-mannosidase, II, Glycosylases, Carbohydrate, Metabolism, Glycosylases, Glycosylases, Tocris Bioscience
