Biological Activity
An effective non-competitive NMDA receptor antagonist in vivo and in vitro; may bind to more than one site, one of which is the polyamine site.
Technical Data
| M. Wt | 354.47 |
| Formula | C12H28N6.H2SO4 |
| Storage | Store at RT |
| CAS Number | 182285-12-7 |
| PubChem ID | 66977 |
| InChI Key | OZZMUVKANAPKGI-UHFFFAOYSA-N |
| Smiles | OS(O)(=O)=O.NC(=N)NCCCCCCCCCCNC(N)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 5 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 354.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.11 mL | 28.21 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Reynolds et al (1991) 1,10-Bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo. J.Pharmacol.Exp.Ther. 259 626 PMID: 1658306
Reynolds (1992) Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex: clues to the mechanism of action of 1,10-bis(guanidino)decane and pentamidine. J.Pharmacol.Exp.Ther. 263 632 PMID: 1432693
Keywords: Synthalin sulfate, supplier, Non-competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
