Biological Activity
Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.
Licensing Information
Sold with the permission of Tanabe Seiyaku Co. Ltd.
Compound Libraries
T 0156 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 620.06 |
| Formula | C31H29N5O7.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 324572-93-2 |
| PubChem ID | 9852041 |
| InChI Key | RBJCBXAXUHCWBR-UHFFFAOYSA-N |
| Smiles | Cl.COC(=O)C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C2=CC=NC(OCC3=NC=CC=N3)=C2C(=O)N1CC1=CC=NC(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.59 | 25mM with gentle warming | |
| ethanol | 14.59 | 25mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 620.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.61 mL | 8.06 mL | 16.13 mL |
| 5 mM | 0.32 mL | 1.61 mL | 3.23 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.61 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
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References
References are publications that support the products' biological activity.
Mochida et al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91 PMID: 12450574
Mochida et al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283 PMID: 14757152
Keywords: T 0156 hydrochloride, supplier, potent, selective, PDE5, inhibitors, inhibits, Phosphodiesterases, T0156, hydrochloride, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience
