Biological Activity
The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.
Technical Data
| M. Wt | 101.1 |
| Formula | C4H7NO2 |
| Storage | Store at RT |
| CAS Number | 38090-53-8 |
| PubChem ID | 5310987 |
| InChI Key | FMKJUUQOYOHLTF-OWOJBTEDSA-N |
| Smiles | NC/C=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 101.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.89 mL | 49.46 mL | 98.91 mL |
| 5 mM | 1.98 mL | 9.89 mL | 19.78 mL |
| 10 mM | 0.99 mL | 4.95 mL | 9.89 mL |
| 50 mM | 0.2 mL | 0.99 mL | 1.98 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551 PMID: 9422798
Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157 PMID: 234147
Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319 PMID: 8885697
Keywords: TACA, supplier, GABAA, agonists, GABA-T, GABA, uptake, inhibitors, inhibits, GABAC, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABAA, Receptors, GABAA-rho, Receptors, GABA, Transporters, GABAA, Receptors, Tocris Bioscience
