Biological Activity
Potent FAAH inhibitor; (IC50 values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.
Technical Data
| M. Wt | 397.38 |
| Formula | C19H17F2N7O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1143578-94-2 |
| PubChem ID | 57749996 |
| InChI Key | JCWVFSJNIBAGQN-UHFFFAOYSA-N |
| Smiles | FC1=CC(C2=NC(N3CCN(C(NC4=CC=CN=N4)=O)CC3)=NC=C2)=CC=C1F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 7.95 | 20 | |
| DMSO | 3.97 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 397.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kono et al (2014) Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorg.Med.Chem. 22 1468 PMID: 24440478
Keywords: TAK 21d, supplier, TAK21d, potent, inhibitors, inhibits, fatty, acid, amide, hydrolase, FAAH, neuropathic, inflammatory, pain, analgesic, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, Fatty, Acid, Amide, Hydrolase, (FAAH), Tocris Bioscience
