Tocris/TAK 715/4254/50/50 mg
商品编号：
4254/50
市场价：
¥16500.00
美元价：
9900.00
产品分类：
其它酶
公司分类：
Other_enzymes
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Potentp38MAPKinhibitor;anti-inflammatory
ChemicalName:N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitorofp38MAPK(IC50=7.1nMforp38MAPKα).AlsoinhibitsWnt-3a-stimulatedβ-cateninsignaling.Inhibits22kinasesbymorethan80%,includingCK1δ/ε.Anti-inflammatoryandanti-rheumatoidarthritisagent.Orallybioavailable.
CompoundLibraries
TAK715isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 399.51 |
| Formula | C24H21N3OS |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 303162-79-0 |
| PubChemID | 90488922 |
| InChIKey | BRYAJHADJWBFQY-UHFFFAOYSA-N |
| Smiles | CCC1=NC(C3=CC(C)=CC=C3)=C(C2=C(NC(C4=CC=CC=C4)=O)N=CC=C2)S1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.95 | 100 | |
| ethanol | 19.98 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight399.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.5mL | 12.52mL | 25.03mL |
| 5mM | 0.5mL | 2.5mL | 5.01mL |
| 10mM | 0.25mL | 1.25mL | 2.5mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet