Biological Activity
GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
Technical Data
| M. Wt | 339.5 |
| Formula | C15H17NO2S3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 207306-50-1 |
| PubChem ID | 6918633 |
| InChI Key | QILRYFCEXLFIDS-UHFFFAOYSA-N |
| Smiles | O=C2C1=C(SCCO)SC(C3=NC=CS3)=C1CC(C)(C)C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.95 | 100 | |
| ethanol | 8.49 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 339.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.73 mL | 29.46 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chambers et al (2003) Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition. J.Med.Chem. 46 2227 PMID: 12747794
Keywords: TB 21007, supplier, α5, alpha5-selective, GABAA, inverse, agonists, Receptors, TB21007, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
