BiologicalActivity
Acell-permeable,selectiveinhibitorofcaseinkinase-2(CK2)(IC50=0.9and1.6μMforratliverandhumanrecombinantCK2respectively).ExhibitsmodestdiscriminationbetweenCK2subunits,withKivaluesrangingfrom80nMto210nM.ActsinanATP/GTP-competitivemanneranddisplaysonetotwoordersofmagnitudeselectivityoverapanelof33proteinkinases.
CompoundLibraries
TBBisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 434.71 |
| Formula | C6HBr4N3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 17374-26-4 |
| PubChemID | 1694 |
| InChIKey | OMZYUVOATZSGJY-UHFFFAOYSA-N |
| Smiles | BrC1=C2NN=NC2=C(Br)C(Br)=C1Br |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.47 | 100 | |
| ethanol | 6.52 | 15 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight434.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.3mL | 11.5mL | 23mL |
| 5mM | 0.46mL | 2.3mL | 4.6mL |
| 10mM | 0.23mL | 1.15mL | 2.3mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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ProductDatasheets
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