Biological Activity
High affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.
Technical Data
| M. Wt | 297.37 |
| Formula | C19H20FNO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 362512-81-0 |
| PubChem ID | 10040286 |
| InChI Key | FYGREZKTJIXWIH-UHFFFAOYSA-N |
| Smiles | OC12C3C4C5C3C(C3C5CC4C13)N2CCC1=CC(F)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.87 | 50mM with gentle warming | |
| ethanol | 14.87 | 50mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 297.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.36 mL | 16.81 mL | 33.63 mL |
| 5 mM | 0.67 mL | 3.36 mL | 6.73 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.36 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Liu et al (2007) Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects. Eur.J.Pharmacol. 555 37 PMID: 17113074
Keywords: TC 1, supplier, High, affinity, σ1, sigma1, ligands, Receptors, TC1, Sigma1, Receptors, Sigma1, Receptors, Tocris Bioscience
