Biological Activity
Selective nicotinic α7 receptor agonist (EC50 = 440 nM). Also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Neuroprotective.
Technical Data
| M. Wt | 275.22 |
| Formula | C13H18N2.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 787587-06-8 |
| PubChem ID | 21094258 |
| InChI Key | ZQUQBCHNSBJMCG-UHFFFAOYSA-N |
| Smiles | C1(C2N3CCC(CC3)CC2)=CC=CN=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.52 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 275.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.63 mL | 18.17 mL | 36.33 mL |
| 5 mM | 0.73 mL | 3.63 mL | 7.27 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.63 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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References
References are publications that support the products' biological activity.
Marrero et al (2004) The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel α7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J.Pharmacol.Exp.Ther. 309 16 PMID: 14722323
Papke et al (2005) Rhesus monkey α7 nicotinic acetylcholine receptors: comparisons to human α7 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 524 11 PMID: 16266703
Keywords: TC 1698 dihydrochloride, supplier, α7, alpha7-selective, agonists, α7Nicotinic, a7Nicotinic, Receptors, Acetylcholine, nAChR, TC1698, dihydrochloride, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience
