Tocris/Lonafarnib/6265/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Lonafarnib/6265/50/50 mg

Tocris/Lonafarnib/6265/50/50 mg

商品编号： 6265/50

品牌： Tocris Bioscience

市场价： ¥10500.00

美元价： 6300.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Potentfarnesyltransferaseinhibitor

ChemicalName:4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentfarnesyltransferaseinhibitor(IC₅₀=1.9nM).InhibitsfarnesylationofRAS.AlsoinhibitsPgptransport(IC₅₀<3=""μm)=""and=""increases=""potency=""and=""anticancer=""activity=""when=""used=""in=""conjunction=""with=""cytotoxic=""pgp=""substrates.=""inhibits=""neovascularization=""by=""affecting=""cell=""motility.=""orally="">

TechnicalData

M.Wt	638.82
Formula	C₂₇H₃₁Br₂ClN₄O₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	193275-84-2
PubChemID	148195
InChIKey	DHMTURDWPRKSOA-RUZDIDTESA-N
Smiles	NC(N1CCC(CC1)CC(N2CCC([C@H]3C4=NC=C(C=C4CCC5=CC(Cl)=CC(Br)=C35)Br)CC2)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	6.39	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight638.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.57mL	7.83mL	15.65mL
5mM	0.31mL	1.57mL	3.13mL
10mM	0.16mL	0.78mL	1.57mL
50mM	0.03mL	0.16mL	0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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