Biological Activity
Potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.
Compound Libraries
TC-A 2317 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 392.93 |
| Formula | C19H28N6O.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1245907-03-2 |
| PubChem ID | 46911725 |
| InChI Key | DXVATYHPJJPMIN-UHFFFAOYSA-N |
| Smiles | CC1=CC(NC2=NNC(C)=C2)=NC(NC(C)CCCC(C)(C)O)=C1C#N.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.29 | 100 | |
| ethanol | 19.65 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 392.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.72 mL | 25.45 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.09 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ando et al (2010) 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors. Bioorg.Med.Chem.Lett. 20 4709 PMID: 20573509
Keywords: TC-A 2317 hydrochloride, supplier, inhibits, aurora, kinase, a, inhibitors, antitumor, Aurora, A, Aurora, Kinases, Aurora, Kinases, Tocris Bioscience
