Biological Activity
Potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).
Technical Data
| M. Wt | 276.29 |
| Formula | C17H12N2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 2360773 |
| InChI Key | GFGMISOSPOPSHN-NOCYUORASA-N |
| Smiles | O=C1OC(/C=C/C3=CC=CC=C3)=NC1=C/C2=CC=CN=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.81 | 50 | |
| ethanol | 2.76 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 276.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.62 mL | 18.1 mL | 36.19 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.62 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Okamoto et al (2009) Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 52 7323 PMID: 19877644
Keywords: TC-DAPK 6, supplier, TC-DAPK6, death-associated, protein, kinase, dapk1, selective, potent, inhibitors, inhibits, 315694-89-4, DAPK, DAPK, Tocris Bioscience
