Biological Activity
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.
Technical Data
| M. Wt | 268.78 |
| Formula | C14H20N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| PubChem ID | 91826083 |
| InChI Key | WKUCMHGVDQUBMQ-HTKOBJQYSA-N |
| Smiles | CC[C@@H](C)[C@H](N)C(N1CC(C=CC=C2)=C2C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.23 | 100 | |
| water | 23.23 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 268.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.72 mL | 18.6 mL | 37.21 mL |
| 5 mM | 0.74 mL | 3.72 mL | 7.44 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Lankas et al (2005) Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54 2988 PMID: 16186403
Wu et al (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem.Pharmacol. 78 203 PMID: 19439267
Van der Veken et al (2007) Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J.Med.Chem. 50 5568 PMID: 17958345
Keywords: TC-E 5007, supplier, TC-E5007, 956039079, 956039_07_9, irreversible, selective, dipeptidyl, peptidases, DPP-8, DPP-9, inhibitors, inhibits, allo-I1e-isoindoline, Other, Proteases, Other, Proteases, Tocris Bioscience
