Biological Activity
Potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.
Compound Libraries
TC-FPR 43 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 384.86 |
| Formula | C20H21ClN4O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 903895-98-7 |
| PubChem ID | 24776341 |
| InChI Key | PAEBEUZTAPIOIO-UHFFFAOYSA-N |
| Smiles | CC(C)C1=C(NC(NC3=CC=C(Cl)C=C3)=O)C(N(C2=CC=CC=C2)N1C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.49 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 384.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.6 mL | 12.99 mL | 25.98 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Dufton et al (2010) Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 184 2611 PMID: 20107188
Bürli et al (2006) Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 16 3713 PMID: 16697190
Forsman et al (2011) Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 81 402 PMID: 21095183
Keywords: TC-FPR 43, supplier, TC-FPR43, potent, FPR2, anti-inflammatory, GPR32, agonists, neutrophils, migration, inflammation, anti-inflammatory, Formyl, Peptide, Receptors, Formyl, Peptide, Receptors, Tocris Bioscience
