Biological Activity
Potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.
Technical Data
| M. Wt | 330.73 |
| Formula | C15H11ClN4O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1257256-44-2 |
| PubChem ID | 49857866 |
| InChI Key | JYCNWQGNEJYDQS-UHFFFAOYSA-N |
| Smiles | CC(C=C3)=C(Cl)C=C3NC1=NN=C(C2=CC=C([N+]([O-])=O)C=C2)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.31 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 330.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.02 mL | 15.12 mL | 30.24 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.05 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.02 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534 PMID: 21082766
Keywords: TC-G 24, supplier, TC-G24, glycogen, synthase, kinase, 3, beta, b, β, gsk3beta, gsk3β, potent, inhibits, inhibitors, selective, brain, penetrant, liver, hinge, region, binder, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Glycogen, Synthase, Kinase, 3, Tocris Bioscience
