Biological Activity
TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM).
Compound Libraries
TC-I 2000 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 414.4 |
| Formula | C23H18F4N2O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1159996-20-9 |
| PubChem ID | 57326210 |
| InChI Key | ADCDUDFEGFKKQH-UHFFFAOYSA-N |
| Smiles | O=C(NC3=CC=C(F)C=C3)N2C(C4=CC=C(C(F)(F)F)C=C4)C1=CC=CC=C1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.44 | 100 | |
| ethanol | 8.29 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 414.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Tamayo et al (2012) Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. J.Med.Chem. 55 1593 PMID: 22329507
Keywords: TC-I 2000, supplier, TCI2000, TRPM8, transient, receptor, potential, channels, blockers, TRPM, TRPM, Tocris Bioscience
