Biological Activity
Potent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.
Technical Data
| M. Wt | 408.47 |
| Formula | C24H25FN2O3 |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 864756-35-4 |
| PubChem ID | 11654412 |
| InChI Key | ANCFKYJMXNMYNZ-UHFFFAOYSA-N |
| Smiles | O=C1C=C(OCC3=CC=C(F)C=C3)C=CN1C2=CC=C(OCCN4CCCC4)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 40.85 | 100 | |
| DMSO | 20.42 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 408.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.24 mL | 24.48 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Haga et al (2011) Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 19 883 PMID: 21190859
Ito et al (2009) Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 624 77 PMID: 19836369
Keywords: TC-MCH 7c, supplier, TCMCH7c, obese, potent, selective, MCH, MCHR, MCH1R, MCHR1, antagonists, melanin, concentrating, hormones, receptors, Melanin-concentrating, Hormone, Receptors, Melanin-concentrating, Hormone, Receptors, Tocris Bioscience
