Biological Activity
Selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Displays no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7).
Technical Data
| M. Wt | 258.32 |
| Formula | C14H18N4O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 873398-67-5 |
| PubChem ID | 59598765 |
| InChI Key | RAKSAPLZNJXYRB-UHFFFAOYSA-N |
| Smiles | NC1=NC(N)=NC=C1OC2=C(C(C)C)C=CC(C)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 258.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.87 mL | 19.36 mL | 38.71 mL |
| 5 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.87 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ballini et al (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br.J.Pharmacol. 163 1315 PMID: 21410458
Keywords: TC-P 262, supplier, Selective, P2X3, P2X2/3, receptors, antagonists, TC-P262, P2X, Receptors, P2X, Receptors, Tocris Bioscience
