BiologicalActivity
Potentinhibitoroflymphocytespecifickinase(Lck).IC50valuesare0.007,0.021,0.042and0.20μMforLck,Lyn,SrcandSykkinasesrespectively.Displays>1000-foldselectivityforLckoverMAPK,CDKandRSKfamilyrepresentatives.InhibitsTcellproliferationinvitroandinhibitsarthritisintwoinvivomodels.Orallyactive.
CompoundLibraries
TC-S7003isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 530.62 |
| Formula | C31H30N8O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 847950-09-8 |
| PubChemID | 11785878 |
| InChIKey | BHJJWVDKNXABFS-UHFFFAOYSA-N |
| Smiles | O=C3N(C4=C(C)C=CC=C4C)C1=NC7=C(C=CC=C7)N1C2=NC(NC5=CC=C(N6CCN(C)CC6)C=C5)=NC=C23 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.06 | 100 | |
| ethanol | 5.31 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight530.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.88mL | 9.42mL | 18.85mL |
| 5mM | 0.38mL | 1.88mL | 3.77mL |
| 10mM | 0.19mL | 0.94mL | 1.88mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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ProductDatasheets
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